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Seventy-five patients with AD(87.2%)and 13 of the mixed group(76.5%)had abnormal EEGs on first testing,giving a sensitivity of 87.2%for uncomplicated AD.Ultimately,79(92%)of 86 patients with AD had abnormal EEGs.Twenty(35%)of 56 EEGs for matching control subjects were abnormal. Moderately abnormal or severely abnormal EEGs were found in 10(50%)of 20 of the patients with AD of less than 4 years'duration compared with two(4. 1%)of 49 of the control subjects,giving a specificity of 95.9%for EEGs with this degree of abnormality.The normal EEG had a negative predictive value of 0.825 with respect to the diagnosis of AD in these populations. Widespread availability,low cost,and high sensitivity support the use of the awake EEG in the diagnosis of AD. |
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Alzheimer's disease
Alzheimer's disease,diagnosis of
dementia,diagnostic evaluation of
dementia,differential diagnosis of
dementia,presenile
electroencephalogram
electroencephalogram,abnormalities of
neurologic disease,diagnoses of
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